“Perhaps there is no disease that this miracle molecule cannot help protect against.”

Louis J. Ignarro (1998, Nobel Prize in Physiology or Medicine)

콘텐츠 편집
콘텐츠 편집

Signaling
Molecule of Life,
Nitric Oxide

“Perhaps there is no disease that this miracle molecule cannot help protect against.”

Louis J. Ignarro, a Professor at the UCLA School of Medicine, was awarded the Nobel Prize in Physiology or Medicine in 1998 for his groundbreaking discovery of Nitric Oxide.

Nitric Oxide: The Signal Molecule of Life

Nitric oxide is an essential signaling molecule that plays a crucial role in various biological systems, opening up new possibilities for the treatment of cardiovascular diseases. In particular, it has been found that nitric oxide is key not only for vascular health but also for the proper functioning of the immune system, nervous system, and digestive tract.

Vasodilation & Increased Blood Flow

Relaxes vascular smooth muscles, which dilates blood vessels and increases blood flow.
Effects
  • High Blood Pressure
  • Angina
  • Arteriosclerosis
  • Numbness in Hands and Feet

Blood Purification

Helps purify the blood by preventing blood clot formation and strengthening the immune system.
Effects
  • Diabetes
  • Fatigue
  • Obesity
  • Fatty Liver

Angiogenesis

Plays a critical role by stimulating vascular endothelial cells to create new blood vessels.
Effects
  • Dementia Prevention
  • Wound Healing
  • Anti-Aging
  • Immune Regulation

Immune Recovery

Works by acting on various cells within the immune system to regulate immune responses.
Effects
  • Pathogens
  • Harmful Substances
  • Viruses
  • Toxins

Homeostasis Regulation

Plays a crucial role in maintaining homeostasis by regulating various processes within the body.
Effects
  • Temperature Regulation
  • pH Balance
  • Fluid Balance
  • Blood Sugar Regulation
  • Blood Pressure Regulation

History of Nitric Oxide

Research on nitric oxide has driven significant advances in various fields such as biology, medicine, and pharmacology since the 1980s. Nitric oxide remains a key subject in life sciences and is expected to contribute to the treatment and prevention of various diseases in the future.

1980s

Discovery of Nitric Oxide’s Role as a Signaling Molecule

Throughout the 1980s, continuous research findings revealed that nitric oxide plays an important role as a biological signaling molecule, emerging as a promising new avenue for the treatment of cardiovascular diseases.

1992

Nitric Oxide Selected as "Molecule of the Year"

In recognition of its significance, in 1992 the prestigious weekly scientific journal Science—published by the American Association for the Advancement of Science (AAAS)—designated nitric oxide as the “Molecule of the Year.”

1998

Nobel Prize in Physiology or Medicine Awarded

The pioneers in nitric oxide research—Robert F. Furchgott, Ferid Murad, and Louis J. Ignarro—were awarded the Nobel Prize in Physiology or Medicine in 1998 for their groundbreaking work demonstrating the role and effects of nitric oxide as a signaling molecule in the cardiovascular system.

2000s

Continuous Advancements in Research

Since the 20th century, nitric oxide research has become one of the most prolific fields, with numerous published papers. It has been revealed that nitric oxide plays a crucial role not only in vascular health but also in various biological systems including the central nervous system, respiratory system, digestive system, sexual function, and immune system. As a result, research into the development of therapies for related diseases is actively progressing.

The Significance of Nitric Oxide

One person dies every 6 seconds worldwide from vascular disease.*

The primary cause of “vascular disease” is the reduced production of nitric oxide in the body due to aging.
(* Source: 2019 World Health Organization (WHO) Vascular Disease Mortality Statistics)
The Significance of Nitric Oxide

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